Metabolic Pathways Underlying Cow’s Milk Allergy in Children: a Metabolomics Approach

De Paepe, Ellen
Faculteit Diergeneeskunde
Vakgroep Translationele Fysiologie, Infectiologie en Volksgezondheid
Ellen De Paepe was born on 18 November 1992 (Ghent, Belgium). She obtained a Master of Veterinary Medicine, main subject Research, magna cum laude at Ghent University, Belgium in 2016. Shortly after her graduation, Ellen was employed as a Ph.D. student at the Laboratory for Integrative Metabolomics, Faculty of Veterinary Medicine, Ghent University. Her doctoral research was funded by the Flanders Research Foundation. In January 2019, Ellen was granted the opportunity for a 3-week research stay at the Folkhälsan Research Center at the University of Helsinki, Finland. Ellen De Paepe is the author and co-author of 12 journal articles and contributed to several national and international conferences. In this context, Ellen received 2 poster awards, i.e. at the Global Food Security Summit and the Ghent Gut Inflammation Group meeting. In 2022 Ellen obtained her certificate from the Doctoral School of Life Sciences and Medicine.
Academische graad
Doctor in de diergeneeskundige wetenschappen
Taal proefschrift
Prof. dr. Lynn Vanhaecke, Faculty of Veterinary Medicine, UGent - Prof. dr. Eric Cox, Faculty of Veterinary Medicine, UGent

Korte beschrijving

Over the last decades, food allergies (FAs) have become a growing epidemic, especially in industrialized countries. One of the first allergies to occur in early childhood is cow’s milk allergy (CMA), which is a first indication that the immune system is not developing properly. Indeed, the majority of children with CMA outgrow this allergy, but develop other atopic diseases later in life, including atopic dermatitis, allergic rhinitis, and asthma. This phenomenon is also described as the atopic march. Despite the increasing prevalence of FAs and more specifically CMA, current diagnostic, treatment, and prevention strategies are unfortunately insufficient, thereby negatively affecting the quality of life of the patients and their caretakers. In this regard, more research is urgently needed to unravel the pathophysiology behind this disease. Therefore, the overarching aim of this Ph.D. thesis was to contribute to elucidating the metabolic disturbances that precede or accompany CMA development. This was effectuated by using untargeted ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS)- based metabolomics and/or lipidomics in an in vivo murine model, a pediatric patient cohort (n = 81) and an in vitro gastrointestinal digestion model.


Maandag 3 oktober 2022, 17:00
Diergeneeskunde AUD D, Salisburylaan 133, 9820 Merelbeke

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